Boosting of activity enhancement of K(+)-responsive quadruplex hammerhead ribozyme.
Chem Commun (Camb)
; 51(27): 5898-901, 2015 Apr 07.
Article
em En
| MEDLINE
| ID: mdl-25727931
ABSTRACT
Two second-generation quadruplex hammerhead ribozymes, whose activity enhances in response to K(+)via quadruplex formation of embedded r(GGA)3GG, were developed. Different strategies were applied to suppress basal activity when K(+) is absent. As a result, the activity enhancement upon the addition of K(+) has reached as high as 21-fold.
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Base de dados:
MEDLINE
Assunto principal:
Potássio
/
Técnicas Biossensoriais
/
RNA Catalítico
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article