Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.

Alinari, Lapo; Mahasenan, Kiran V; Yan, Fengting; Karkhanis, Vrajesh; Chung, Ji-Hyun; Smith, Emily M; Quinion, Carl; Smith, Porsha L; Kim, Lisa; Patton, John T; Lapalombella, Rosa; Yu, Bo; Wu, Yun; Roy, Satavisha; De Leo, Alessandra; Pileri, Stefano; Agostinelli, Claudio; Ayers, Leona; Bradner, James E; Chen-Kiang, Selina; Elemento, Olivier; Motiwala, Tasneem; Majumder, Sarmila; Byrd, John C; Jacob, Samson; Sif, Said; Li, Chenglong; Baiocchi, Robert A

Alinari, Lapo; Mahasenan, Kiran V; Yan, Fengting; Karkhanis, Vrajesh; Chung, Ji-Hyun; Smith, Emily M; Quinion, Carl; Smith, Porsha L; Kim, Lisa; Patton, John T; Lapalombella, Rosa; Yu, Bo; Wu, Yun; Roy, Satavisha; De Leo, Alessandra; Pileri, Stefano; Agostinelli, Claudio; Ayers, Leona; Bradner, James E; Chen-Kiang, Selina; Elemento, Olivier; Motiwala, Tasneem; Majumder, Sarmila; Byrd, John C; Jacob, Samson; Sif, Said; Li, Chenglong; Baiocchi, Robert A.

Afiliação

Alinari L; Division of Hematology, Department of Internal Medicine.
Mahasenan KV; Division of Medicinal Chemistry and Pharmacognosy, and.
Yan F; Division of Hematology, Department of Internal Medicine.
Karkhanis V; Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH;
Chung JH; Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH;
Smith EM; Division of Hematology, Department of Internal Medicine.
Quinion C; Division of Hematology, Department of Internal Medicine.
Smith PL; Division of Hematology, Department of Internal Medicine.
Kim L; Division of Hematology, Department of Internal Medicine.
Patton JT; Division of Hematology, Department of Internal Medicine.
Lapalombella R; Division of Hematology, Department of Internal Medicine.
Yu B; Division of Hematology, Department of Internal Medicine.
Wu Y; Division of Hematology, Department of Internal Medicine.
Roy S; Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH;
De Leo A; Department of Public Health and Infectious Diseases, University La Sapienza, Rome, Italy;
Pileri S; Hematopathology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy;
Agostinelli C; Hematopathology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy;
Ayers L; Department of Pathology, The Ohio State University, Columbus, OH;
Bradner JE; Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;
Chen-Kiang S; Department of Pathology and Laboratory Medicine, and.
Elemento O; Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY; and.
Motiwala T; Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH;
Majumder S; Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH;
Byrd JC; Division of Hematology, Department of Internal Medicine, Division of Medicinal Chemistry and Pharmacognosy, and.
Jacob S; Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH;
Sif S; Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar.
Li C; Division of Medicinal Chemistry and Pharmacognosy, and.
Baiocchi RA; Division of Hematology, Department of Internal Medicine.

Blood ; 125(16): 2530-43, 2015 Apr 16.

Article em En | MEDLINE | ID: mdl-25742700

Assuntos

Linfócitos B/efeitos dos fármacos; Transformação Celular Viral/efeitos dos fármacos; Inibidores Enzimáticos/farmacologia; Proteína-Arginina N-Metiltransferases/antagonistas & inibidores; Animais; Linfócitos B/metabolismo; Linfócitos B/virologia; Western Blotting; Linhagem Celular Transformada; Transformação Celular Viral/genética; Células Cultivadas; Herpesvirus Humano 4/fisiologia; Histona Desacetilases/genética; Histona Desacetilases/metabolismo; Interações Hospedeiro-Patógeno/efeitos dos fármacos; Humanos; Linfoma/genética; Linfoma/metabolismo; Linfoma/virologia; Camundongos SCID; MicroRNAs/genética; MicroRNAs/metabolismo; Microscopia Confocal; Proteína-Arginina N-Metiltransferases/genética; Proteína-Arginina N-Metiltransferases/metabolismo; Interferência de RNA; Proteínas Tirosina Fosfatases Classe 3 Semelhantes a Receptores/genética; Proteínas Tirosina Fosfatases Classe 3 Semelhantes a Receptores/metabolismo; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Bibliotecas de Moléculas Pequenas/farmacologia; Fator de Transcrição RelA/genética; Fator de Transcrição RelA/metabolismo; Transcriptoma/efeitos dos fármacos; Transcriptoma/genética; Proteínas Supressoras de Tumor/genética; Proteínas Supressoras de Tumor/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína-Arginina N-Metiltransferases / Linfócitos B / Transformação Celular Viral / Inibidores Enzimáticos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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