[Epileptic encephalopathy associated with human herpes virus 6 (HHV-6) encephalitis after the second cord blood transplantation in a patient with pediatric acute lymphoblastic leukemia].
Rinsho Ketsueki
; 55(12): 2418-22, 2014 Dec.
Article
em Ja
| MEDLINE
| ID: mdl-25744043
ABSTRACT
The incidence of HHV-6 encephalitis during hematopoietic stem cell transplantation (HSCT) in children is thought to be less than that in adults and risk factors, prognosis and complications are virtually unknown. Herein, we report a pediatric case developing epileptic encephalopathy following HHV-6 encephalitis after a second cord blood transplantation (CBT). A 7-year-old boy with relapsed B-precursor acute lymphoblastic leukemia in second remission underwent CBT. However, he received a second CBT due to graft failure. On day 25 after the second CBT, he developed short-term memory defects and seizures. He was diagnosed with HHV-6 encephalitis because HHV-6 DNA was detected in his blood and cerebrospinal fluid and abnormal hippocampal signals were seen on cranial magnetic resonance imaging (MRI). After treatment with foscarnet, HHV-6 DNA levels and MRI findings improved; however, he developed epileptic encephalopathy five months after the onset of encephalitis. There are very few reports on pediatric epileptic encephalopathy associated with HHV-6 encephalitis after HSCT. Detailed studies are needed to analyze risk factors, prognosis, and complications.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Herpesvirus Humano 6
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Encefalite Viral
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Transplante de Células-Tronco de Sangue do Cordão Umbilical
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Epilepsia
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Leucemia-Linfoma Linfoblástico de Células Precursoras
Idioma:
Ja
Ano de publicação:
2014
Tipo de documento:
Article