Evaluation of drug loading, pharmacokinetic behavior, and toxicity of a cisplatin-containing hydrogel nanoparticle.

Kai, Marc P; Keeler, Amanda W; Perry, Jillian L; Reuter, Kevin G; Luft, J Christopher; O'Neal, Sara K; Zamboni, William C; DeSimone, Joseph M

Kai, Marc P; Keeler, Amanda W; Perry, Jillian L; Reuter, Kevin G; Luft, J Christopher; O'Neal, Sara K; Zamboni, William C; DeSimone, Joseph M.

Afiliação

Kai MP; Department of Chemical and Biomolecular Engineering, North Carolina State University, 911 Partners Way, Raleigh, NC 27599, USA. Electronic address: mpkai@ncsu.edu.
Keeler AW; Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 257 Caudill Lab, Chapel Hill, NC 27599, USA.
Perry JL; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 257 Caudill Lab, Chapel Hill, NC 27599, USA.
Reuter KG; Department of Chemistry, University of North Carolina at Chapel Hill, 257 Caudill Lab, Chapel Hill, NC 27599, USA.
Luft JC; Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 257 Caudill Lab, Chapel Hill, NC 27599, USA.
O'Neal SK; Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 257 Caudill Lab, Chapel Hill, NC 27599, USA.
Zamboni WC; Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 257 Caudill Lab, Chapel Hill, NC 27599, USA.
DeSimone JM; Department of Chemical and Biomolecular Engineering, North Carolina State University, 911 Partners Way, Raleigh, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 257 Caudill Lab, Chapel Hill, NC 27599, USA; Department of Chemistry, University of Nor

J Control Release ; 204: 70-7, 2015 Apr 28.

Article em En | MEDLINE | ID: mdl-25744827

Assuntos

Antineoplásicos/farmacologia; Antineoplásicos/farmacocinética; Cisplatino/farmacologia; Cisplatino/farmacocinética; Portadores de Fármacos/química; Hidrogéis/química; Nanopartículas/química; Animais; Antineoplásicos/administração & dosagem; Antineoplásicos/toxicidade; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Cisplatino/administração & dosagem; Cisplatino/toxicidade; Composição de Medicamentos; Dose Máxima Tolerável; Camundongos Endogâmicos C57BL; Neoplasias Experimentais/tratamento farmacológico

Palavras-chave

Cisplatin; Cytotoxicity; PEGylation; PRINT; Pharmacokinetics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Cisplatino / Hidrogéis / Nanopartículas / Antineoplásicos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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