Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis.
Anticancer Res
; 35(3): 1459-64, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25750298
ABSTRACT
BACKGROUND:
The function of phosphatidylserine-specific phospholipase A1 (PS-PLA1), a phospholipase that acts specifically on phosphatidylserine and produces lysophosphatidylserine, a lysophospholipid mediator, has not been fully elucidated. We evaluated the role of PS-PLA1 in oncogenesis and metastasis of colorectal cancer (CRC). MATERIALS ANDMETHODS:
Specimens from 85 patients with CRC were immunostained with a monoclonal antibody against PS-PLA1. The correlation between PS-PLA1 expression and the clinicopathological variables was analyzed.RESULTS:
Tumor depth and hematogenous metastasis independently positively correlated with PS-PLA1 expression. High PS-PLA1 expression was associated with shorter disease-free survival, although it was not an independent predictive factor.CONCLUSION:
PS-PLA1 expression in CRC is associated with tumor invasion and metastasis.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Fosfatidilserinas
/
Neoplasias Colorretais
/
Fosfolipases A1
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article