Microwave-assisted synthesis, molecular docking, and cholinesterase inhibitory activities of new ethanediamide and 2-butenediamide analogues.
Chem Pharm Bull (Tokyo)
; 63(3): 210-7, 2015.
Article
em En
| MEDLINE
| ID: mdl-25757492
ABSTRACT
A novel series of meta-substituted ethanediamide and 2-butenediamide derivatives were synthesized and tested for their ability to inhibit electric eel acetylcholinesterase (AChE) and equine serum butyrylcholinesterase (BuChE). The synthesized compounds were evaluated against ChE enzymes using the colorimetric method described by Ellman et al. (Biochem. Pharmacol., 7, 1961). It was revealed that some synthesized compounds exhibited high anticholinesterase activity, among which compounds 1f and 2f were the most active inhibitors against BuChE (IC50 value=1.47 µM) and AChE (IC50 value=2.09 µM), respectively. Docking simulations revealed that the inhibitors 1f and 2f are capable of simultaneously binding the peripheral anionic site as well as the catalytic anionic site of both ChE enzymes. These derivatives are considered interesting candidates for Alzheimer's disease treatment.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxalatos
/
Crotonatos
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Química Farmacêutica
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Inibidores da Colinesterase
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Micro-Ondas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article