Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index.
J Gerontol A Biol Sci Med Sci
; 70(8): 1003-8, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-25758594
ABSTRACT
BACKGROUND:
The Healthy Aging Index (HAI) is a tool for measuring the extent of health and disease across multiple systems.METHODS:
We conducted a genome-wide association study and a genome-wide linkage analysis to map quantitative trait loci associated with the HAI and a modified HAI weighted for mortality risk in 3,140 individuals selected for familial longevity from the Long Life Family Study. The genome-wide association study used the Long Life Family Study as the discovery cohort and individuals from the Cardiovascular Health Study and the Framingham Heart Study as replication cohorts.RESULTS:
There were no genome-wide significant findings from the genome-wide association study; however, several single-nucleotide polymorphisms near ZNF704 on chromosome 8q21.13 were suggestively associated with the HAI in the Long Life Family Study (p < 10(-) (6)) and nominally replicated in the Cardiovascular Health Study and Framingham Heart Study. Linkage results revealed significant evidence (log-odds score = 3.36) for a quantitative trait locus for mortality-optimized HAI in women on chromosome 9p24-p23. However, results of fine-mapping studies did not implicate any specific candidate genes within this region of interest.CONCLUSIONS:
ZNF704 may be a potential candidate gene for studies of the genetic underpinnings of longevity.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Estudo de Associação Genômica Ampla
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Ligação Genética
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article