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Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound.
Sola, Irene; Viayna, Elisabet; Gómez, Tània; Galdeano, Carles; Cassina, Matteo; Camps, Pelayo; Romeo, Margherita; Diomede, Luisa; Salmona, Mario; Franco, Pilar; Schaeffer, Mireille; Colantuono, Diego; Robin, David; Brunner, Daniela; Taub, Nicole; Hutter-Paier, Birgit; Muñoz-Torrero, Diego.
Afiliação
  • Sola I; Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, Barcelona E-08028, Spain. irenesola872@gmail.com.
  • Viayna E; Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, Barcelona E-08028, Spain. elisabet.viayna@gmail.com.
  • Gómez T; Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, Barcelona E-08028, Spain. tania.gomez.nadal@gmail.com.
  • Galdeano C; Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, Barcelona E-08028, Spain. cargalcan@hotmail.com.
  • Cassina M; Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, Barcelona E-08028, Spain. matteo.cassina01@universitadipavia.it.
  • Camps P; Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, Barcelona E-08028, Spain. camps@ub.edu.
  • Romeo M; Department of Molecular Biochemistry and Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, Milan 20156, Italy. margherita.romeo@marionegri.it.
  • Diomede L; Department of Molecular Biochemistry and Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, Milan 20156, Italy. luisa.diomede@marionegri.it.
  • Salmona M; Department of Molecular Biochemistry and Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, Milan 20156, Italy. mario.salmona@marionegri.it.
  • Franco P; Chiral Technologies Europe, Parc d'Innovation, Bd. Gonthier d'Andernach, Illkirch F-67400, France. pfranco@chiral.fr.
  • Schaeffer M; Chiral Technologies Europe, Parc d'Innovation, Bd. Gonthier d'Andernach, Illkirch F-67400, France. mschaeffer@chiral.fr.
  • Colantuono D; Chiral Technologies Europe, Parc d'Innovation, Bd. Gonthier d'Andernach, Illkirch F-67400, France. dcolantuono@chiral.fr.
  • Robin D; Chiral Technologies Europe, Parc d'Innovation, Bd. Gonthier d'Andernach, Illkirch F-67400, France. drobin@chiral.fr.
  • Brunner D; Neuropharmacology Department of QPS Austria-Gmbh, Parkring 12, Grambach 8074, Austria. Daniela.Brunner@qps.com.
  • Taub N; Neuropharmacology Department of QPS Austria-Gmbh, Parkring 12, Grambach 8074, Austria. Nicole.Taub@qps.com.
  • Hutter-Paier B; Neuropharmacology Department of QPS Austria-Gmbh, Parkring 12, Grambach 8074, Austria. Birgit.Hutter-Paier@qps.com.
  • Muñoz-Torrero D; Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, Barcelona E-08028, Spain. dmunoztorrero@ub.edu.
Molecules ; 20(3): 4492-515, 2015 Mar 10.
Article em En | MEDLINE | ID: mdl-25764491
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Encéfalo / Precursor de Proteína beta-Amiloide / Doença de Alzheimer / Aminoquinolinas / Compostos Heterocíclicos de 4 ou mais Anéis / Indanos Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Encéfalo / Precursor de Proteína beta-Amiloide / Doença de Alzheimer / Aminoquinolinas / Compostos Heterocíclicos de 4 ou mais Anéis / Indanos Idioma: En Ano de publicação: 2015 Tipo de documento: Article