Prognostic impact of elevation of vascular endothelial growth factor family expression in patients with non-small cell lung cancer: an updated meta-analysis.
Asian Pac J Cancer Prev
; 16(5): 1881-95, 2015.
Article
em En
| MEDLINE
| ID: mdl-25773840
ABSTRACT
BACKGROUND:
The vascular endothelial growth factor family has been implicated in tumorigenesis and metastasis. The prognostic value of each vascular endothelial growth factor family member, particular VEGF/ VEGFR co-expression, in patients with non-small lung cancer remains controversial. MATERIALS ANDMETHODS:
Relevant literature was identified by searching PubMed, EMBASE and Web of Science. Studies evaluating expression of VEGFs and/or VEGFRs by immunohistochemistry or ELISA in lung cancer tissue were eligible for inclusion. Hazard ratios (HRs) and 95% confidence intervals (CIs) from individual study were pooled by using a fixed- or random-effect model, heterogeneity and publication bias analyses were also performed.RESULTS:
74 studies covering 7,631 patients were included in the meta-analysis. Regarding pro-angiogenesis factors, the expression of VEGFA (HR=1.633, 95%CI 1.490-1.791) and VEGFR1 (HR=1.924, 95%CI 1.220-3.034) was associated separately with poor survival. Especially, VEGFA over-expression was an independent prognostic factor in adenocarcinoma (ADC) (HR=1.775, 95%CI 1.384-2.275) and SCC (HR=2.919, 95%CI 2.060-4.137). Co-expression of VEGFA/VEGFR2 (HR=2.011, 95%CI 1.405-2.876) was also significantly associated with worse survival. For lymphangiogenesis factors, the expression of VEGFC (HR=1.611, 95%CI 1.407-1.844) predicted a poor prognosis. Co-expression of VEGFC/VEGFR3 (HR=2.436, 95%CI 1.468-4.043) emerged as a preferable prognostic marker.CONCLUSIONS:
The expression of VEGFA (particularly in SCC and early stage NSCLC), VEGFC, VEGFR1 indicates separately an unfavorable prognosis in patients with NSCLC. Co-expression VEGFA/ VEGFR2 is comparable with VEGFC/VEGFR3, both featuring sufficient discrimination value as preferable as prognostic biologic markers.
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Carcinoma Pulmonar de Células não Pequenas
/
Receptores de Fatores de Crescimento do Endotélio Vascular
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Fatores de Crescimento do Endotélio Vascular
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Neoplasias Pulmonares
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article