Telaprevir decreases estimated glomerular filtration rate in HIV-hepatitis C virus coinfected patients.
AIDS
; 29(8): 977-9, 2015 May 15.
Article
em En
| MEDLINE
| ID: mdl-25784438
ABSTRACT
We investigated kidney function outcome in 24 chronic hepatitis C genotype 1 patients coinfected with HIV receiving telaprevir in a single tertiary care hospital in Spain. A statistically significant median (interquartile range) decrease in estimated glomerular filtration rate (eGFR, ml/min/1.73 m) relative to baseline [93.6 (73.0-109.0)] was seen at weeks 4 [86.5 (34.0-112.0), P = 0.014], 8 [90.0 (49.0-111.0), P = 0.026] and 12 [89.5 (54.0-113.0), P = 0.017]. These changes reversed after telaprevir discontinuation. Patients presenting an eGFR decrease had a higher risk of haematological toxicity.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
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Infecções por HIV
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Hepatite C Crônica
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Coinfecção
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Taxa de Filtração Glomerular
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article