A prospective, split-face, randomized study of the efficacy and safety of a novel fractionated intense pulsed light treatment for melasma in Asians.
J Cosmet Laser Ther
; 17(5): 259-66, 2015.
Article
em En
| MEDLINE
| ID: mdl-25803571
ABSTRACT
BACKGROUND:
Intense pulsed light (IPL) has been reported to effectively treat melasma in previous studies, but an aggravation of pigmentation was noted. Fractionated IPL is a novel technique in which microsecond-domain fractionated pulses are delivered to the target area.OBJECTIVE:
To compare the safety and efficacy of low-fluency, frequently scheduled fractionated IPL and conventional IPL for melasma treatment. MATERIALS ANDMETHODS:
This was a 14-week, split-face study in which 30 Asian women were treated with weekly fractionated IPL on one side of the face and biweekly conventional IPL on the other side.RESULTS:
The non-inferiority of a weekly fractionated IPL regimen to a biweekly conventional IPL regimen was verified by a lower margin of the 95% confidence interval for the difference in the Melasma Area and Severity Index (MASI) change from baseline of 2.61 for each side. This value was greater than the previously determined non-inferiority margin of -2.68 (P < 0.025). On the fractionated IPL side, the modified MASI score decreased continuously, but in the conventional IPL group, the MASI score rebounded during the treatment course.CONCLUSION:
Fractionated IPL shows moderate efficacy as a melasma treatment and is therefore a good alternative to conventional IPL as there is no indication of melasma exacerbation. Fractionated IPL can also be used as a maintenance treatment for melasma.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Técnicas Cosméticas
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Povo Asiático
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Face
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Terapia de Luz Pulsada Intensa
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Melanose
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article