Fighting the force: Potential of homeobox genes for tumor microenvironment regulation.
Biochim Biophys Acta
; 1855(2): 248-53, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25818365
ABSTRACT
Tumor cells exist in a constantly evolving stromal microenvironment composed of vasculature, immune cells and cancer-associated fibroblasts, all residing within a dynamic extracellular matrix. In this review, we examine the biochemical and biophysical interactions between these various stromal cells and their matrix microenvironment. While the stroma can alter tumor progression via multiple mechanisms, we emphasize the role of homeobox genes in detecting and modulating the mechanical changes in the microenvironment during tumor progression.
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Base de dados:
MEDLINE
Assunto principal:
Células Estromais
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Proteínas de Homeodomínio
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Microambiente Tumoral
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Neoplasias
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article