[Gefitinib versus Erlotinib as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer].
Nan Fang Yi Ke Da Xue Xue Bao
; 35(3): 446-9, 2015 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-25818798
ABSTRACT
OBJECTIVE:
To compare the efficacy of the erlotinib versus gefitinib in the first-line treatment of patients with advanced EGFR mutation-positive NSCLC.METHODS:
Fifty patients with untreated advanced EGFR mutation- positive NSCLC were randomly divided into gefitinib group (n=27) and erlotinib group (n=23). The progression-free survival, objective response rate and disease control rate were evaluated to compare the efficacy of gefitinib and erlotinib.RESULTS:
There were no significant differences in the objective response rate (P=0.711) and disease control rate (P=0.861) between the two groups. The progression-free survival of gefitinib group and erlotinib group was 8.0 months and 10.0 months, respectively. The efficacy of the two drugs was similar (P=0.293).CONCLUSION:
There is no significant differences between gefitinib and erlotinib in the first-line treatment of patients with advanced EGFR mutation-positive NSCLC.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Quinazolinas
/
Carcinoma Pulmonar de Células não Pequenas
/
Neoplasias Pulmonares
Idioma:
Zh
Ano de publicação:
2015
Tipo de documento:
Article