Neuron-restrictive silencer factor in periaqueductal gray contributes to remifentanil-induced postoperative hyperalgesia via repression of the mu-opioid receptor.

Lu, Cui'e; Shi, Linyu; Zhang, Juan; Kong, Mingjian; Liu, Yue; Zhou, Yu; Xu, Li; He, Jianhua; Ma, Zhengliang; Gu, Xiaoping

Lu, Cui'e; Shi, Linyu; Zhang, Juan; Kong, Mingjian; Liu, Yue; Zhou, Yu; Xu, Li; He, Jianhua; Ma, Zhengliang; Gu, Xiaoping.

Afiliação

Lu C; Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, 321 Zhong Shan North Road, Nanjing 210008, Jiangsu Province, China. Electronic address: lucuie608@163.com.
Shi L; Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, 321 Zhong Shan North Road, Nanjing 210008, Jiangsu Province, China. Electronic address: mengmeng19880914@163.com.
Zhang J; Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, 321 Zhong Shan North Road, Nanjing 210008, Jiangsu Province, China. Electronic address: zhangjuanju@163.com.
Kong M; Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing 210008, Jiangsu Province China. Electronic address: 778974454@qq.com.
Liu Y; Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, 321 Zhong Shan North Road, Nanjing 210008, Jiangsu Province, China. Electronic address: liuyueseu@163.com.
Zhou Y; Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, 321 Zhong Shan North Road, Nanjing 210008, Jiangsu Province, China. Electronic address: zymzk608@163.com.
Xu L; Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, 321 Zhong Shan North Road, Nanjing 210008, Jiangsu Province, China. Electronic address: 13913846977@126.com.
He J; Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing 210008, Jiangsu Province China. Electronic address: 1198364794@qq.com.
Ma Z; Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, 321 Zhong Shan North Road, Nanjing 210008, Jiangsu Province, China. Electronic address: mazhengliang1964@nju.edu.cn.
Gu X; Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical College of Nanjing University, 321 Zhong Shan North Road, Nanjing 210008, Jiangsu Province, China. Electronic address: 13813996903@126.com.

J Neurol Sci ; 352(1-2): 48-52, 2015 May 15.

Article em En | MEDLINE | ID: mdl-25819118

Assuntos

Hiperalgesia/metabolismo; Substância Cinzenta Periaquedutal/metabolismo; Receptores Opioides mu/metabolismo; Proteínas Repressoras/metabolismo; Animais; Modelos Animais de Doenças; Hiperalgesia/induzido quimicamente; Hiperalgesia/tratamento farmacológico; Injeções Intraventriculares; Camundongos; Camundongos Endogâmicos C57BL; Oligonucleotídeos Antissenso/administração & dosagem; Oligonucleotídeos Antissenso/farmacologia; Substância Cinzenta Periaquedutal/efeitos dos fármacos; Piperidinas/toxicidade; Remifentanil; Proteínas Repressoras/antagonistas & inibidores; Resultado do Tratamento

Palavras-chave

Neuron-restrictive silencer factor; Periaqueductal gray; Postoperative hyperalgesia; Remifentanil; mu-Opioid receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Substância Cinzenta Periaquedutal / Receptores Opioides mu / Hiperalgesia Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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