DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status.
J Venom Anim Toxins Incl Trop Dis
; 21: 10, 2015.
Article
em En
| MEDLINE
| ID: mdl-25821459
ABSTRACT
BACKGROUND:
Jorge Lobo's disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.METHODS:
DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).RESULTS:
The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.CONCLUSION:
These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.
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MEDLINE
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article