RASSF1A gene methylation is associated with nasopharyngeal carcinoma risk in Chinese.
Asian Pac J Cancer Prev
; 16(6): 2283-7, 2015.
Article
em En
| MEDLINE
| ID: mdl-25824751
ABSTRACT
In order to explore the association between RASSF1A methylation and nasopharyngeal carcinoma (NPC) risk of Chinese, we carried out a meta-analysis with searches of PubMed, Web of Science, ProQest and Medline databases. Ultimately, 14 articles were identified and analysised using R Software (R version 3.1.2) including meta packages. Overall, we found a significant relationship between RASSF1A methylation and NPC risk (OR 30.7; 95 % CI, 16.71~56.23; z=11.0591; p<0.0001) in a fixed effects model and (OR 32.1; 95% CI, 14.27~72.01; z=8.3984; p<0.0001) in a random effects model pooled. In tissue and NP brushings groups , similar results were found. Hence, our study identified a strong association between RASSF1A methylation and NPC and highlighted a promising potential for RASSF1A methylation in NPC risk prediction of Chinese.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Nasofaríngeas
/
Metilação de DNA
/
Proteínas Supressoras de Tumor
/
Povo Asiático
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article