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Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
Hayashi, Yohei; Caboni, Laura; Das, Debanu; Yumoto, Fumiaki; Clayton, Thomas; Deller, Marc C; Nguyen, Phuong; Farr, Carol L; Chiu, Hsiu-Ju; Miller, Mitchell D; Elsliger, Marc-André; Deacon, Ashley M; Godzik, Adam; Lesley, Scott A; Tomoda, Kiichiro; Conklin, Bruce R; Wilson, Ian A; Yamanaka, Shinya; Fletterick, Robert J.
Afiliação
  • Hayashi Y; Gladstone Institutes of Cardiovascular Disease, San Francisco, CA 94158;
  • Caboni L; Department of Biochemistry and Biophysics, and.
  • Das D; Joint Center for Structural Genomics, Stanford Synchrotron Radiation Lightsource, Stanford Linear Accelerator Center National Accelerator Laboratory, Menlo Park, CA 94025;
  • Yumoto F; Department of Biochemistry and Biophysics, and Structural Biology Research Center, KEK High Energy Accelerator Research Organization, Tsukuba, Ibaraki 305-0801, Japan;
  • Clayton T; Joint Center for Structural Genomics, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037;
  • Deller MC; Joint Center for Structural Genomics, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037;
  • Nguyen P; Department of Biochemistry and Biophysics, and.
  • Farr CL; Joint Center for Structural Genomics, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037;
  • Chiu HJ; Joint Center for Structural Genomics, Stanford Synchrotron Radiation Lightsource, Stanford Linear Accelerator Center National Accelerator Laboratory, Menlo Park, CA 94025;
  • Miller MD; Joint Center for Structural Genomics, Stanford Synchrotron Radiation Lightsource, Stanford Linear Accelerator Center National Accelerator Laboratory, Menlo Park, CA 94025;
  • Elsliger MA; Joint Center for Structural Genomics, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037;
  • Deacon AM; Joint Center for Structural Genomics, Stanford Synchrotron Radiation Lightsource, Stanford Linear Accelerator Center National Accelerator Laboratory, Menlo Park, CA 94025;
  • Godzik A; Joint Center for Structural Genomics, Center for Research in Biological Systems, University of California, San Diego, La Jolla, CA 92037; Program on Bioinformatics and Systems Biology, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037;
  • Lesley SA; Joint Center for Structural Genomics, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037; Protein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121; and.
  • Tomoda K; Gladstone Institutes of Cardiovascular Disease, San Francisco, CA 94158;
  • Conklin BR; Gladstone Institutes of Cardiovascular Disease, San Francisco, CA 94158; Departments of Medicine, Anatomy, Medical Genetics, and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158;
  • Wilson IA; Joint Center for Structural Genomics, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037;
  • Yamanaka S; Gladstone Institutes of Cardiovascular Disease, San Francisco, CA 94158; Department of Reprogramming Science, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan yamanaka@cira.kyoto-u.ac.jp robert.fletterick@ucsf.edu.
  • Fletterick RJ; Department of Biochemistry and Biophysics, and yamanaka@cira.kyoto-u.ac.jp robert.fletterick@ucsf.edu.
Proc Natl Acad Sci U S A ; 112(15): 4666-71, 2015 Apr 14.
Article em En | MEDLINE | ID: mdl-25825768
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Homeodomínio / Células-Tronco Pluripotentes / Proliferação de Células / Reprogramação Celular / Mutação Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Homeodomínio / Células-Tronco Pluripotentes / Proliferação de Células / Reprogramação Celular / Mutação Idioma: En Ano de publicação: 2015 Tipo de documento: Article