Simple "on-demand" production of bioactive natural products.
Chembiochem
; 16(7): 1115-9, 2015 May 04.
Article
em En
| MEDLINE
| ID: mdl-25826784
ABSTRACT
Exchange of the native promoter to the arabinose-inducible promoter PBAD was established in entomopathogenic bacteria to silence and/or activate gene clusters involved in natural product biosynthesis. This allowed the "on-demand" production of GameXPeptides, xenoamicins, and the blue pigment indigoidine. The gene clusters for the novel "mevalagmapeptides" and the highly toxic xenorhabdins were identified by this approach.
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MEDLINE
Assunto principal:
Produtos Biológicos
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Engenharia Genética
Idioma:
En
Ano de publicação:
2015
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Article