Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine.
Prog Biophys Mol Biol
; 118(1-2): 21-33, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-25839742
ABSTRACT
Familial inheritance of drug abuse is composed of both genetic and environmental factors. Additionally, epigenetic transgenerational inheritance may provide a means by which parental drug use can influence several generations of offspring. Recent evidence suggests that parental drug exposure produces behavioral, biochemical, and neuroanatomical changes in future generations. The focus of this review is to discuss these multigenerational and transgenerational phenotypes in the offspring of animals exposed to drugs of abuse. Specifically, changes found following the administration of alcohol, opioids, cocaine, marijuana, and nicotine will be discussed. In addition, epigenetic modifications to the genome following administration of these drugs will be detailed as well as their potential for transmission to the next generation.
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Base de dados:
MEDLINE
Assunto principal:
Cannabis
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Cocaína
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Transtornos Relacionados ao Uso de Substâncias
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Padrões de Herança
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Álcoois
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Exposição Ambiental
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Analgésicos Opioides
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Nicotina
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article