Evaluation of Th17 pathway in the diagnosis of autosomal dominant polycystic kidney disease.
Iran J Kidney Dis
; 9(2): 105-12, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25851288
ABSTRACT
INTRODUCTION:
Current assessment tools of autosomal dominant polycystic kidney disease (ADPKD) diagnosis are challenging. This study evaluated the possible application of assessment of interleukin (IL)-17-related cytokines and the circulatory T helper 17 cells in the diagnosis of ADPKD. MATERIALS ANDMETHODS:
Enrolling 54 ADPKD patients and 54 healthy individuals, we measured serum and urine levels of IL-6, IL-17, IL-23, and transforming growth factor-ß and the peripheral blood frequency of T helper 17 cells through flowcytometry. We computed sensitivity and specificity of each inflammatory marker as well as their different combinations using the receiver operating characteristic curve and discriminant function analysis.RESULTS:
The mean serum and urine levels of IL-17 and IL-23 as well as urine levels of IL-6 were higher in ADPKD patients compared to the healthy controls (P < .001). There was no significant difference in the number of T helper 17 cells between the two groups. Among different combinations of the inflammatory markers, the serum IL-17 was the best factor in the diagnosis of ADPKD with a sensitivity as well as specificity of 100%.CONCLUSIONS:
It is likely that T helper 17 pathway is involved in the pathogenesis of ADPKD; therefore, it may be beneficial if such a pathway be considered in its diagnosis.
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Base de dados:
MEDLINE
Assunto principal:
Rim Policístico Autossômico Dominante
/
Células Th17
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article