Cobalt(II) catalyzed C(sp)-H bond functionalization of alkynes with phenyl hydrazines: facile access to diaryl 1,2-diketones.
Org Biomol Chem
; 13(18): 5235-42, 2015 May 14.
Article
em En
| MEDLINE
| ID: mdl-25856782
ABSTRACT
A cobalt acetylacetonate catalyzed oxidative diketonation of alkynes via C(sp)-H bond functionalization has been described. The reaction involves a free-radical mechanism, wherein the phenyl radical formed from phenyl hydrazine couples with Co(II) activated alkyne to produce 1,2-diketones. The reaction proceeds at room temperature in DMF with the use of Ag2O/air as the oxidizing system. The utility of the protocol for the synthesis of a series of imidazoles including a potent platelet aggregation inhibitor trifenagrel has been demonstrated.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cobalto
/
Alcinos
/
Hidrazinas
/
Ligação de Hidrogênio
/
Cetonas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article