Metronomic capecitabine as second-line treatment in hepatocellular carcinoma after sorafenib failure.
Dig Liver Dis
; 47(6): 518-22, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25861840
ABSTRACT
BACKGROUND:
No standard second-line treatments are available for hepatocellular carcinoma patients who fail sorafenib therapy. We assessed the safety and efficacy of metronomic capecitabine after first-line sorafenib failure.METHODS:
Retrospective analysis of consecutive hepatocellular carcinoma patients receiving metronomic capecitabine between January 2012 and November 2014. The primary end-point was safety, secondary end-point was efficacy, including time-to-progression and overall survival.RESULTS:
Twenty-six patients (80% Child-Pugh A, 80% Barcelona Clinic Liver Cancer stage C) received metronomic capecitabine (500 mg/bid). Median treatment duration was 3.2 months (range 0.6-31). Fourteen (53%) patients experienced at least one adverse event. The most frequent drug-related adverse events were bilirubin elevation (23%), fatigue (15%), anaemia (11%), lymphoedema (11%), and hand-foot syndrome (7.6%). Treatment was interrupted in 19 (73%) for disease progression, in 4 (15%) for liver deterioration, and in 1 (3.8%) for adverse event. Disease control was achieved in 6 (23%) patients. Median time-to-progression was 4 months (95% confidence interval 3.2-4.7). Median overall survival was 8 months (95% confidence interval 3.7-12.3).CONCLUSIONS:
Metronomic capecitabine was well tolerated in hepatocellular carcinoma patients who had been treated with sorafenib. Preliminary data show potential anti-tumour activity with long-lasting disease control in a subgroup of patients that warrants further evaluation in a phase III study.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Compostos de Fenilureia
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Niacinamida
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Carcinoma Hepatocelular
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Capecitabina
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Neoplasias Hepáticas
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Antineoplásicos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article