Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity.
Arch Pharm (Weinheim)
; 348(5): 315-29, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25864390
ABSTRACT
The active form of vitamin D3, 1α,25(OH)2D3, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and pro-differentiating agent. Unfortunately, it usually causes hypercalcemia in vivo when effective antitumour doses are used. It has therefore been found necessary to synthesise new analogues that retain or even increase the antitumour effects but preclude hypercalcemia. This report presents the synthesis of a novel Gemini vitamin D analogue (UVB1) and its biological evaluation. We demonstrate that this compound has potent antitumoural effects over a wide panel of tumour cell lines while showing lack of hypercalcemic activity and toxicity effects in in vivo assays.
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Base de dados:
MEDLINE
Assunto principal:
Vitamina D
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Proliferação de Células
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Hipercalcemia
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Neoplasias
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Antineoplásicos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article