Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B.

Potts, Malia B; McMillan, Elizabeth A; Rosales, Tracy I; Kim, Hyun Seok; Ou, Yi-Hung; Toombs, Jason E; Brekken, Rolf A; Minden, Mark D; MacMillan, John B; White, Michael A

Potts, Malia B; McMillan, Elizabeth A; Rosales, Tracy I; Kim, Hyun Seok; Ou, Yi-Hung; Toombs, Jason E; Brekken, Rolf A; Minden, Mark D; MacMillan, John B; White, Michael A.

Afiliação

Potts MB; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
McMillan EA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Rosales TI; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Kim HS; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ou YH; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Toombs JE; Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Brekken RA; Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Minden MD; 1] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [2] Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
MacMillan JB; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
White MA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Nat Chem Biol ; 11(6): 401-8, 2015 Jun.

Article em En | MEDLINE | ID: mdl-25867045

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Depsipeptídeos/farmacologia; Proteínas de Membrana/antagonistas & inibidores; Fator 1 de Elongação de Peptídeos/antagonistas & inibidores; Farmacogenética; Apoptose/genética; Biomarcadores/metabolismo; Linhagem Celular Tumoral; Estudo de Associação Genômica Ampla; Humanos; Alvo Mecanístico do Complexo 1 de Rapamicina; Proteínas de Membrana/genética; Complexos Multiproteicos/genética; Complexos Multiproteicos/metabolismo; Fator 1 de Elongação de Peptídeos/genética; Biossíntese de Proteínas/efeitos dos fármacos; Biossíntese de Proteínas/genética; Serina-Treonina Quinases TOR/genética; Serina-Treonina Quinases TOR/metabolismo; Tioléster Hidrolases; Fatores de Transcrição/antagonistas & inibidores; Fatores de Transcrição/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Farmacogenética / Apoptose / Fator 1 de Elongação de Peptídeos / Depsipeptídeos / Proteínas de Membrana / Antineoplásicos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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