Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus.

Hughes, J; Wang, P; Alusi, G; Shi, H; Chu, Y; Wang, J; Bhakta, V; McNeish, I; McCart, A; Lemoine, N R; Wang, Y

Hughes, J; Wang, P; Alusi, G; Shi, H; Chu, Y; Wang, J; Bhakta, V; McNeish, I; McCart, A; Lemoine, N R; Wang, Y.

Afiliação

Hughes J; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Wang P; Sino-British Research Centre for Molecular Oncology, Zhengzhou University, Zhengzhou, China.
Alusi G; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Shi H; Sino-British Research Centre for Molecular Oncology, Zhengzhou University, Zhengzhou, China.
Chu Y; Sino-British Research Centre for Molecular Oncology, Zhengzhou University, Zhengzhou, China.
Wang J; Sino-British Research Centre for Molecular Oncology, Zhengzhou University, Zhengzhou, China.
Bhakta V; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
McNeish I; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
McCart A; 1] Department of Surgery, University of Toronto, Toronto, ON, Canada [2] Division of Experimental Therapeutics, Toronto-General Research Institute, Toronto, ON, Canada.
Lemoine NR; 1] Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK [2] Sino-British Research Centre for Molecular Oncology, Zhengzhou University, Zhengzhou, China.
Wang Y; 1] Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK [2] Sino-British Research Centre for Molecular Oncology, Zhengzhou University, Zhengzhou, China.

Gene Ther ; 22(6): 476-84, 2015 Jun.

Article em En | MEDLINE | ID: mdl-25876464

Assuntos

Deleção de Genes; Vírus Oncolíticos/fisiologia; Timidina Quinase/genética; Vaccinia virus/genética; Animais; Linhagem Celular; Linhagem Celular Tumoral; Chlorocebus aethiops; Modelos Animais de Doenças; Terapia Genética; Humanos; Rim/citologia; Camundongos; Mutação; Neoplasias/terapia; Vírus Oncolíticos/genética; Vacina Antivariólica/genética; Vacina Antivariólica/uso terapêutico; Replicação Viral

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Timidina Quinase / Vaccinia virus / Deleção de Genes / Vírus Oncolíticos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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