Caspase-8 functions as a key mediator of inflammation and pro-IL-1ß processing via both canonical and non-canonical pathways.
Immunol Rev
; 265(1): 181-93, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25879293
ABSTRACT
Caspase-8 is an apical component of cell death pathways. Activated caspase-8 can drive classical caspase-dependent apoptosis and actively inhibits cell death mediated by RIPK3-driven necroptosis. Genetic deletion of Casp8 results in embryonic lethality as a result of uncontrolled necroptosis. This lethality can be rescued by simultaneous deletion of Ripk3. Recently, caspase-8 has been additionally connected to inflammatory pathways within the cell. In particular, caspase-8 has been shown to be crucially involved in the induction of pro-IL-1ß synthesis and processing via both non-canonical and canonical pathways. In this review, we bring together current knowledge regarding the role of caspase-8 in cellular inflammation with a particular emphasis on the interplay between caspase-8 and the classical and non-canonical inflammasomes.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Caspase 8
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Interleucina-1beta
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Inflamassomos
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Inflamação
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article