Light therapy and serotonin transporter binding in the anterior cingulate and prefrontal cortex.
Acta Psychiatr Scand
; 132(5): 379-88, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-25891484
ABSTRACT
OBJECTIVE:
To investigate the effects of light therapy on serotonin transporter binding (5-HTT BPND ), an index of 5-HTT levels, in the anterior cingulate and prefrontal cortices (ACC and PFC) of healthy individuals during the fall and winter. Twenty-five per cent of healthy individuals experience seasonal mood changes that affect functioning. 5-HTT BPND has been found to be higher across multiple brain regions in the fall and winter relative to spring and summer, and elevated 5-HTT BPND may lead to extracellular serotonin loss and low mood. We hypothesized that, during the fall and winter, light therapy would reduce 5-HTT BPND in the ACC and PFC, which sample brain regions involved in mood regulation.METHOD:
In a single-blind, placebo-controlled, counterbalanced, crossover design, [(11) C]DASB positron emission tomography was used measure 5-HTT BPND following light therapy and placebo conditions during fall and winter.RESULTS:
In winter, light therapy significantly decreased 5-HTT BPND by 12% in the ACC relative to placebo (F1,9 = 18.04, P = 0.002). In the fall, no significant change in 5-HTT BPND was found in any region across conditions.CONCLUSION:
These results identify, for the first time, a central biomarker associated with the intervention of light therapy in humans which may be applied to further develop this treatment for prevention of seasonal depression.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fototerapia
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Estações do Ano
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Córtex Pré-Frontal
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Tomografia por Emissão de Pósitrons
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Proteínas da Membrana Plasmática de Transporte de Serotonina
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Giro do Cíngulo
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article