Your browser doesn't support javascript.
loading
Prognostic Significance of 1-Year Serum Albumin Levels Within the Normal Range After Kidney Transplantation.
Oh, Il Hwan; Park, Joon-Sung; Lee, Chang Hwa; Kang, Chong Myung; Kim, Gheun-Ho.
Afiliação
  • Oh IH; Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • Park JS; Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • Lee CH; Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • Kang CM; Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • Kim GH; Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Artif Organs ; 39(11): 965-72, 2015 Nov.
Article em En | MEDLINE | ID: mdl-25894393
Hypoalbuminemia is associated with poor outcomes in kidney transplantation (KT). However, what level is optimal in serum albumin is not clear for the long-term prognosis. To determine whether the long-term outcomes are different even between the normal ranges of serum albumin after KT, we analyzed data from 404 renal allograft recipients whose 1-year post-transplant serum albumin levels were within the normal limits (3.5-5.5 g/dL). During a follow-up of 122 ± 56 months, 97 graft losses, 20 patient deaths, and 50 cardiovascular (CV) events occurred. Based on 1-year serum albumin levels, the patients were divided into high normal (≥4.6 g/dL, n = 209) and low normal (<4.6 g/dL, n = 195) groups. Kaplan-Meier analyses revealed that the low normal group had poorer allograft survival (P = 0.01), patient survival (P < 0.001), and CV event-free survival (P < 0.001) than the high normal group. Cox regression analysis confirmed that 1-year serum albumin was inversely associated with the risk of graft loss (hazard ratio [HR] 0.414, 95% confidence interval [CI] 0.200-0.856), patient death (HR 0.097, 95% CI 0.019-0.484), and CV events (HR 0.228, 95% CI 0.074-0.702). In conclusion, a relatively low 1-year post-transplant serum albumin level within the normal limits (<4.6 g/dL) significantly predicts poor long-term outcomes.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Albumina Sérica / Transplante de Rim / Rejeição de Enxerto Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Albumina Sérica / Transplante de Rim / Rejeição de Enxerto Idioma: En Ano de publicação: 2015 Tipo de documento: Article