Mild guanidinoacetate increase under partial guanidinoacetate methyltransferase deficiency strongly affects brain cell development.

Hanna-El-Daher, Layane; Béard, Elidie; Henry, Hugues; Tenenbaum, Liliane; Braissant, Olivier

Hanna-El-Daher, Layane; Béard, Elidie; Henry, Hugues; Tenenbaum, Liliane; Braissant, Olivier.

Afiliação

Hanna-El-Daher L; Neurometabolic Unit, Service of Biomedicine, Lausanne University Hospital, CH-1011 Lausanne, Switzerland.
Béard E; Neurometabolic Unit, Service of Biomedicine, Lausanne University Hospital, CH-1011 Lausanne, Switzerland.
Henry H; Neurometabolic Unit, Service of Biomedicine, Lausanne University Hospital, CH-1011 Lausanne, Switzerland.
Tenenbaum L; Department of Clinical Neuroscience, Lausanne University Hospital, CH-1011 Lausanne, Switzerland.
Braissant O; Neurometabolic Unit, Service of Biomedicine, Lausanne University Hospital, CH-1011 Lausanne, Switzerland. Electronic address: Olivier.Braissant@chuv.ch.

Neurobiol Dis ; 79: 14-27, 2015 Jul.

Article em En | MEDLINE | ID: mdl-25896543

Assuntos

Encéfalo/embriologia; Encéfalo/enzimologia; Glicina/análogos & derivados; Guanidinoacetato N-Metiltransferase/deficiência; Animais; Apoptose/fisiologia; Axônios/enzimologia; Células Cultivadas; Técnicas de Cocultura; Creatina/metabolismo; Dependovirus/genética; Vetores Genéticos; Glicina/metabolismo; Guanidinoacetato N-Metiltransferase/genética; Neuroglia/enzimologia; Neurônios/enzimologia; Interferência de RNA; Ratos Sprague-Dawley; Receptores de GABA-A/metabolismo

Palavras-chave

Adeno-associated virus; Brain; Creatine; Creatine deficiency syndromes; Development; GAMT deficiency; Guanidinoacetate; RNA interference

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Guanidinoacetato N-Metiltransferase / Glicina Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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