Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu(A) and lnu(D).

Stogios, Peter J; Evdokimova, Elena; Morar, Mariya; Koteva, Kalinka; Wright, Gerard D; Courvalin, Patrice; Savchenko, Alexei

Stogios, Peter J; Evdokimova, Elena; Morar, Mariya; Koteva, Kalinka; Wright, Gerard D; Courvalin, Patrice; Savchenko, Alexei.

Afiliação

Stogios PJ; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada M5G 1L6; Center for Structural Genomics of Infectious Diseases (CSGID).
Evdokimova E; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada M5G 1L6; Center for Structural Genomics of Infectious Diseases (CSGID).
Morar M; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, MDCL 2301, 1280 Main Street West, Hamilton, Ontario, Canada L8N 3Z5.
Koteva K; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, MDCL 2301, 1280 Main Street West, Hamilton, Ontario, Canada L8N 3Z5.
Wright GD; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, MDCL 2301, 1280 Main Street West, Hamilton, Ontario, Canada L8N 3Z5.
Courvalin P; Unité des Agents Antibacteriens, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France.
Savchenko A; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada M5G 1L6; Center for Structural Genomics of Infectious Diseases (CSGID). Electronic address: alexei.savchenko@utoronto.ca.

J Mol Biol ; 427(12): 2229-43, 2015 Jun 19.

Article em En | MEDLINE | ID: mdl-25900373

Assuntos

Proteínas de Bactérias/química; Proteínas de Bactérias/metabolismo; Farmacorresistência Bacteriana; Nucleotidiltransferases/química; Nucleotidiltransferases/metabolismo; Sequência de Aminoácidos; Proteínas de Bactérias/genética; Domínio Catalítico; Análise por Conglomerados; Cristalografia por Raios X; Lincosamidas/química; Lincosamidas/metabolismo; Dados de Sequência Molecular; Nucleotidiltransferases/genética; Filogenia; Ligação Proteica; Conformação Proteica; Alinhamento de Sequência; Homologia de Sequência de Aminoácidos; Especificidade por Substrato

Palavras-chave

aminoglycoside; antibiotic resistance; crystal structure; lincosamide; nucleotidylyltransferase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Farmacorresistência Bacteriana / Nucleotidiltransferases Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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