Overexpression of feline tripartite motif-containing 25 interferes with the late stage of feline leukemia virus replication.
Virus Res
; 204: 88-94, 2015 Jun 02.
Article
em En
| MEDLINE
| ID: mdl-25913257
ABSTRACT
Tripartite motif-containing 25 (TRIM25) regulates various cellular processes through E3 ubiquitin ligase activity. Previous studies have revealed that the expression of TRIM25 is induced by type I interferon and that TRIM25 is involved in the host cellular innate immune response against retroviral infection. Although retroviral infection is prevalent in domestic cats, the roles of feline TRIM25 in the immune response against these viral infections are poorly understood. Because feline TRIM25 is expected to modulate the infection of feline leukemia virus (FeLV), we investigated its effects on early- and late-stage FeLV replication. This study revealed that ectopic expression of feline TRIM25 in HEK293T cells reduced viral protein levels leading to the inhibition of FeLV release. Our findings show that feline TRIM25 has a potent antiviral activity and implicate an antiviral mechanism whereby feline TRIM25 interferes with late-stage FeLV replication.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Infecções Tumorais por Vírus
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Doenças do Gato
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Interferon Tipo I
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Vírus da Leucemia Felina
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Infecções por Retroviridae
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Ubiquitina-Proteína Ligases
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article