Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection.

Colquhoun, David R; Lyashkov, Alexey E; Ubaida Mohien, Ceereena; Aquino, Veronica N; Bullock, Brandon T; Dinglasan, Rhoel R; Agnew, Brian J; Graham, David R M

Colquhoun, David R; Lyashkov, Alexey E; Ubaida Mohien, Ceereena; Aquino, Veronica N; Bullock, Brandon T; Dinglasan, Rhoel R; Agnew, Brian J; Graham, David R M.

Afiliação

Colquhoun DR; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lyashkov AE; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ubaida Mohien C; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Aquino VN; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bullock BT; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dinglasan RR; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Agnew BJ; Biosciences Group, Thermo Fisher Scientific, Eugene, OR, USA.
Graham DR; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Proteomics ; 15(12): 2066-77, 2015 Jun.

Article em En | MEDLINE | ID: mdl-25914232

Assuntos

Acil Coenzima A/metabolismo; Biomimética; Infecções por HIV/metabolismo; HIV-1/fisiologia; Palmitoil Coenzima A/metabolismo; Proteoma/análise; Proteômica/métodos; Acilação; Aciltransferases/metabolismo; Células Cultivadas; Cromatografia Líquida; Química Click; Eletroforese em Gel Bidimensional; Infecções por HIV/virologia; Humanos; Mapas de Interação de Proteínas; Proteoma/metabolismo; Espectrometria de Massas em Tandem; Proteínas Virais/metabolismo

Palavras-chave

Click-chemistry; HIV; Myristoylation and palmitoylation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Palmitoil Coenzima A / Acil Coenzima A / Infecções por HIV / HIV-1 / Proteoma / Proteômica / Biomimética Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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