Evaluation of the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice.
Acta Cir Bras
; 30(4): 242-6, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25923256
ABSTRACT
PURPOSE:
To evaluate the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice.METHODS:
The anti-inflammatory effect of alcoholic extracts of green tea (AE) was evaluated in a cell migration assay with four groups of six Swiss mice receiving 0.07 g/Kg or 0.14 g/Kg EA (treatment groups), saline (negative control) or 10mg/Kg indomethacin (positive control) by gavage. One hour later 300 µg carrageen an was administered intraperitoneally or subcutaneously. The analgesic effect was evaluated using four groups of six animals receiving 0.07 g/Kg or 0.14 g/Kg EA, saline or 10mg/Kg indomethacin subcutaneously, followed 30 minutes later by 1% acetic acid.RESULTS:
When administered subcutaneously at either dose (0.07 g/Kg and 0.14 g/Kg), AE inhibited carrageenan-induced cell migration (p<0.05). However, when administered by gavage, only the latter (0.14 g/Kg) was efficient (p<0.05). AE at both doses (0.07 g/Kg and 0.14 g/Kg) inhibited abdominal contortions (p<0.05), but the effect was not dose-dependent.CONCLUSION:
Green tea was shown to have analgesic and anti-inflammatory properties and may constitute a natural treatment option in chronic inflammatory disorders.
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Base de dados:
MEDLINE
Assunto principal:
Chá
/
Extratos Vegetais
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Camellia sinensis
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Analgésicos
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Fitoterapia
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Anti-Inflamatórios
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article