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Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway.
Allen, Joshua E; Krigsfeld, Gabriel; Patel, Luv; Mayes, Patrick A; Dicker, David T; Wu, Gen Sheng; El-Deiry, Wafik S.
Afiliação
  • Allen JE; Departments of Medicine, Genetics, and Pharmacology, Laboratory of Molecular Oncology and Cell Cycle Regulation, University of Pennsylvania School of Medicine, Philadelphia, 19104, PA, USA. joshjea@gmail.com.
  • Krigsfeld G; Current affiliation: Oncoceutics, Inc., Hummelstown, PA, USA. joshjea@gmail.com.
  • Patel L; Departments of Medicine, Genetics, and Pharmacology, Laboratory of Molecular Oncology and Cell Cycle Regulation, University of Pennsylvania School of Medicine, Philadelphia, 19104, PA, USA. g.krigsfeld@gmail.com.
  • Mayes PA; Departments of Medicine, Genetics, and Pharmacology, Laboratory of Molecular Oncology and Cell Cycle Regulation, University of Pennsylvania School of Medicine, Philadelphia, 19104, PA, USA. luveroni@gmail.com.
  • Dicker DT; Departments of Medicine, Genetics, and Pharmacology, Laboratory of Molecular Oncology and Cell Cycle Regulation, University of Pennsylvania School of Medicine, Philadelphia, 19104, PA, USA. patrick.mayes@gmail.com.
  • Wu GS; Departments of Medicine, Genetics, and Pharmacology, Laboratory of Molecular Oncology and Cell Cycle Regulation, University of Pennsylvania School of Medicine, Philadelphia, 19104, PA, USA. david.dicker@fccc.edu.
  • El-Deiry WS; Department of Medical Oncology and Molecular Therapeutics Program, Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Fox Chase Cancer Center, Philadelphia, 19111, PA, USA. david.dicker@fccc.edu.
Mol Cancer ; 14: 99, 2015 May 01.
Article em En | MEDLINE | ID: mdl-25927855
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Ligante Indutor de Apoptose Relacionado a TNF / Bibliotecas de Moléculas Pequenas / Compostos Heterocíclicos de 4 ou mais Anéis / Antineoplásicos Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Ligante Indutor de Apoptose Relacionado a TNF / Bibliotecas de Moléculas Pequenas / Compostos Heterocíclicos de 4 ou mais Anéis / Antineoplásicos Idioma: En Ano de publicação: 2015 Tipo de documento: Article