Spin trapping combined with quantitative mass spectrometry defines free radical redistribution within the oxidized hemoglobin:haptoglobin complex.

Vallelian, Florence; Garcia-Rubio, Ines; Puglia, Michele; Kahraman, Abdullah; Deuel, Jeremy W; Engelsberger, Wolfgang R; Mason, Ronald P; Buehler, Paul W; Schaer, Dominik J

Vallelian, Florence; Garcia-Rubio, Ines; Puglia, Michele; Kahraman, Abdullah; Deuel, Jeremy W; Engelsberger, Wolfgang R; Mason, Ronald P; Buehler, Paul W; Schaer, Dominik J.

Afiliação

Vallelian F; Division of Internal Medicine, University Hospital, Zurich, Switzerland.
Garcia-Rubio I; Laboratory of Physical Chemistry, ETH Zürich, Switzerland; Centro Universitario de la Defensa, carretera de Huesca, Zaragoza, Spain.
Puglia M; Division of Internal Medicine, University Hospital, Zurich, Switzerland; Functional Genomics Center, University of Zurich, Switzerland.
Kahraman A; Institute of Molecular Life Sciences, University of Zurich, Switzerland.
Deuel JW; Division of Internal Medicine, University Hospital, Zurich, Switzerland.
Engelsberger WR; Division of Internal Medicine, University Hospital, Zurich, Switzerland.
Mason RP; Laboratory of Toxicology & Pharmacology, NIEHS/NIH, Research Triangle Park, NC, USA.
Buehler PW; Center of Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA.
Schaer DJ; Division of Internal Medicine, University Hospital, Zurich, Switzerland; Institute of Evolutionary Medicine, University of Zurich, Switzerland. Electronic address: dominik.schaer@usz.ch.

Free Radic Biol Med ; 85: 259-68, 2015 Aug.

Article em En | MEDLINE | ID: mdl-25933590

Assuntos

Radicais Livres/metabolismo; Haptoglobinas/metabolismo; Hemoglobinas/metabolismo; Detecção de Spin; Espectrometria de Massas em Tandem/métodos; Sequência de Aminoácidos; Aminoácidos/química; Cromatografia Líquida; Espectroscopia de Ressonância de Spin Eletrônica; Haptoglobinas/química; Hemoglobinas/química; Humanos; Peróxido de Hidrogênio/farmacologia; Dados de Sequência Molecular; Oxirredução; Peroxidases/metabolismo

Palavras-chave

Electron paramagnetic resonance (EPR); Haptoglobin; Hemoglobin; Mass spectrometry; Oxidation; Oxidative stress; Radical; Spin trapping

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Haptoglobinas / Hemoglobinas / Detecção de Spin / Espectrometria de Massas em Tandem / Radicais Livres Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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