Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs.
Trends Cardiovasc Med
; 25(8): 726-35, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-25956433
ABSTRACT
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used medications. NSAIDs profoundly modify prostaglandin homeostasis through inhibition of the enzyme, cyclooxygenase (COX), especially COX-2. COX-2 inhibition is associated with adverse cardiovascular outcomes as demonstrated by recent trials using this type of drug. This review explores the latest available data, including recent, randomized, clinical trials, controversies, and pathophysiology of the adverse effects of COX-inhibition.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
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Anti-Inflamatórios não Esteroides
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Ciclo-Oxigenase 1
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Ciclo-Oxigenase 2
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article