Self-assembling peptide-based delivery of therapeutics for myocardial infarction.
Adv Drug Deliv Rev
; 96: 40-53, 2016 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-25959427
ABSTRACT
Cardiovascular disease, including myocardial infarction, is the number one cause of death. Current treatments are palliative and slow the progression toward heart failure, but to not regenerate healthy tissue. Self-assembling peptides are biomimietic, readily produced, non-immunogenic and non-cytotoxic. They do not assemble into hydrogels until triggered, allowing them to be injected into the myocardium and providing opportunities for minimally invasive therapies. The ability to tune the mechanical and bioactive properties of self-assembling peptides will continue to make them readily adaptable for mimicking natural microenvironments. To date, a variety of growth factors and signaling moieties have been incorporated into self-assembling peptide hydrogels, enhancing cell behavior and tissue function. Furthermore, the hydrogels serve as delivery vehicles for cells in vivo and platforms for improved cell culture. In addition to a brief review of self-assembling peptides, we will discuss a variety of their approaches for myocardial infarction therapy. Moreover, we will assess approaches taken in other tissue and discuss how these could benefit therapies for myocardial infarction.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Sistemas de Liberação de Medicamentos
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Engenharia Tecidual
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Peptídeos e Proteínas de Sinalização Intercelular
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Materiais Biomiméticos
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Infarto do Miocárdio
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article