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Efficacy, but not antibody titer or affinity, of a heroin hapten conjugate vaccine correlates with increasing hapten densities on tetanus toxoid, but not on CRM197 carriers.
Jalah, Rashmi; Torres, Oscar B; Mayorov, Alexander V; Li, Fuying; Antoline, Joshua F G; Jacobson, Arthur E; Rice, Kenner C; Deschamps, Jeffrey R; Beck, Zoltan; Alving, Carl R; Matyas, Gary R.
Afiliação
  • Jalah R; †Laboratory of Adjuvant and Antigen Research, US Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.
  • Torres OB; ‡U.S. Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, 6720A Rockledge Drive, Bethesda, Maryland 20817, United States.
  • Mayorov AV; †Laboratory of Adjuvant and Antigen Research, US Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.
  • Li F; ‡U.S. Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, 6720A Rockledge Drive, Bethesda, Maryland 20817, United States.
  • Antoline JF; †Laboratory of Adjuvant and Antigen Research, US Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.
  • Jacobson AE; ‡U.S. Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, 6720A Rockledge Drive, Bethesda, Maryland 20817, United States.
  • Rice KC; §Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 9800 Medical Drive, Bethesda, Maryland 20892, United States.
  • Deschamps JR; ¶National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9800 Medical Drive, Bethesda, Maryland 20892, United States.
  • Beck Z; §Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 9800 Medical Drive, Bethesda, Maryland 20892, United States.
  • Alving CR; ¶National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9800 Medical Drive, Bethesda, Maryland 20892, United States.
  • Matyas GR; §Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 9800 Medical Drive, Bethesda, Maryland 20892, United States.
Bioconjug Chem ; 26(6): 1041-53, 2015 Jun 17.
Article em En | MEDLINE | ID: mdl-25970207
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Portadores de Fármacos / Toxoide Tetânico / Vacinas Conjugadas / Heroína / Haptenos / Analgésicos Opioides Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Portadores de Fármacos / Toxoide Tetânico / Vacinas Conjugadas / Heroína / Haptenos / Analgésicos Opioides Idioma: En Ano de publicação: 2015 Tipo de documento: Article