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The BH3-mimetic obatoclax reduces HIF-1α levels and HIF-1 transcriptional activity and sensitizes hypoxic colon adenocarcinoma cells to 5-fluorouracil.
Gariboldi, Marzia B; Taiana, Elisa; Bonzi, Maria Chiara; Craparotta, Ilaria; Giovannardi, Stefano; Mancini, Monica; Monti, Elena.
Afiliação
  • Gariboldi MB; Department of Theoretical and Applied Sciences, Division of Biomedical Research, University of Insubria, via A. da Giussano 10, Busto Arsizio, Varese 21052, Italy.
  • Taiana E; Department of Theoretical and Applied Sciences, Division of Biomedical Research, University of Insubria, via A. da Giussano 10, Busto Arsizio, Varese 21052, Italy.
  • Bonzi MC; Department of Theoretical and Applied Sciences, Division of Biomedical Research, University of Insubria, via A. da Giussano 10, Busto Arsizio, Varese 21052, Italy.
  • Craparotta I; Department of Theoretical and Applied Sciences, Division of Biomedical Research, University of Insubria, via A. da Giussano 10, Busto Arsizio, Varese 21052, Italy.
  • Giovannardi S; Department of Theoretical and Applied Sciences, Division of Biomedical Research, University of Insubria, via A. da Giussano 10, Busto Arsizio, Varese 21052, Italy.
  • Mancini M; Department of Theoretical and Applied Sciences, Division of Biomedical Research, University of Insubria, via A. da Giussano 10, Busto Arsizio, Varese 21052, Italy.
  • Monti E; Department of Theoretical and Applied Sciences, Division of Biomedical Research, University of Insubria, via A. da Giussano 10, Busto Arsizio, Varese 21052, Italy. Electronic address: elena.monti@uninsubria.it.
Cancer Lett ; 364(2): 156-64, 2015 Aug 10.
Article em En | MEDLINE | ID: mdl-25979228
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirróis / Adenocarcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias do Colo / Fator 1 Induzível por Hipóxia / Subunidade alfa do Fator 1 Induzível por Hipóxia / Fluoruracila Idioma: En Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirróis / Adenocarcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias do Colo / Fator 1 Induzível por Hipóxia / Subunidade alfa do Fator 1 Induzível por Hipóxia / Fluoruracila Idioma: En Ano de publicação: 2015 Tipo de documento: Article