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IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFß/SMAD signaling-dependent induction of Nox4 and suppression of ANT2.
Hubackova, S; Kucerova, A; Michlits, G; Kyjacova, L; Reinis, M; Korolov, O; Bartek, J; Hodny, Z.
Afiliação
  • Hubackova S; Department of Genome Integrity, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.
  • Kucerova A; Department of Genome Integrity, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.
  • Michlits G; Department of Tumour Immunology, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.
  • Kyjacova L; Department of Genome Integrity, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.
  • Reinis M; Department of Tumour Immunology, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.
  • Korolov O; Department of Tumour Immunology, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.
  • Bartek J; Department of Genome Integrity, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.
  • Hodny Z; Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.
Oncogene ; 35(10): 1236-49, 2016 Mar 10.
Article em En | MEDLINE | ID: mdl-25982278
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Transdução de Sinais / Interferon gama / Senescência Celular / Estresse Oxidativo Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Transdução de Sinais / Interferon gama / Senescência Celular / Estresse Oxidativo Idioma: En Ano de publicação: 2016 Tipo de documento: Article