The design of a spiro-pyrrolidine organocatalyst and its application to catalytic asymmetric Michael addition for the construction of all-carbon quaternary centers.
Chem Commun (Camb)
; 51(49): 9979-82, 2015 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-25998622
ABSTRACT
A novel chiral spiro-pyrrolidine silyl ether organocatalyst has been designed. Its catalytic asymmetric effect is demonstrated by the Michael addition reaction, which affords the desired products with an all-carbon quaternary center in up to 99% ee and 87% yield. Furthermore, the reaction process has been investigated via in situ NMR experiments.
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MEDLINE
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En
Ano de publicação:
2015
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Article