Diverse activity of human secretory phospholipases A2 on the migration of human vascular smooth muscle cells.
Inflamm Res
; 64(7): 497-500, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-25999087
ABSTRACT
OBJECTIVE:
Investigation of the diversity of human secretory phospholipases A2 (sPLA2) on the migration of human vascular smooth muscle cells (VSMC).MATERIAL:
We investigated the impact of sPLA2 IIA, V, and X and of oleic acid, linoleic acid and lysophosphatidylcholine on the migration of human VSMC.METHODS:
Recombinant human sPLA2's and Boyden's chamber method were applied.RESULTS:
sPLA2, IIA but not V or X enhanced migration of VSMC in a dose/time dependent manner. Oleic and linoleic acids, and lysophosphatidylcholine markedly enhanced migration.CONCLUSIONS:
These results imply that sPLA2 IIA, which is known to be present in the arterial wall in the vicinity of VSMC, as well as products of lipid hydrolysis induced by sPLA2, enhance the migration of VSMC, and thus may contribute to atherogenic process.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Miócitos de Músculo Liso
/
Fosfolipases A2 Secretórias
/
Músculo Liso Vascular
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article