Colistin and neurotoxicity: recommendations for optimal use in cystic fibrosis patients.
Int J Clin Pharm
; 37(4): 555-8, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26001357
ABSTRACT
Case description The use of i.v. colistin reappeared recently for the treatment of multidrug-resistant Gram negative organisms in the intensive care and cystic fibrosis (CF) setting. According to the latest pharmacokinetic data, a loading dose and high antibiotic doses are given. Two cases of adverse events (paraesthesias, bad taste) were observed immediately after the start of infusion of a high dose of i.v. colistin in adult CF patients at the Ghent University Hospital. Conclusion Recommendations for optimal administration of i.v. colistin in adult CF patients are scarce. This article highlights the importance of mode of administration to avoid toxicity and relates it to recent pharmacokinetic/-dynamic literature.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por Bactérias Gram-Negativas
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Colistina
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Fibrose Cística
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Antibacterianos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article