JC virus granule cell neuronopathy: A cause of infectious cerebellar degeneration.
J Neurol Sci
; 354(1-2): 86-90, 2015 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-26003226
ABSTRACT
JC virus (JCV) infection of glial cells can lead to progressive multifocal leukoencephalopathy (PML) in immunocompromised patients. A newly described phenotype of the infection is infection of neurons. This distinct clinical and radiological syndrome is named JCV granule cell neuronopathy, characterized by exclusive or predominant cerebellar atrophy. We report the clinical and radiological longitudinal findings of 5 HIV-infected patients referred to us between September 2004 and November 2011 who exhibited JCV granule cell neuronopathy (4 probable cases and 1 possible). The association of immunocompromised status, progressive cerebellar syndrome, MRI abnormalities with cortical cerebellar atrophy and cerebrospinal fluid positive for JCV on PCR allowed for a highly probable diagnosis. The reversal of the immunocompromised status is the only way to stop the disease evolution. Motor functioning can remain impaired, but the illness itself, unlike progressive multifocal leukoencephalopathy, does not seem to threaten life.
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MEDLINE
Assunto principal:
Infecções por HIV
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Doenças Cerebelares
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Leucoencefalopatia Multifocal Progressiva
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Vírus JC
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article