Feasibility of radiation dose reduction using AIDR-3D in dynamic pulmonary CT perfusion.
Clin Radiol
; 70(8): 844-51, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26005001
ABSTRACT
AIM:
To assess the feasibility of radiation dose reduction with adaptive iterative dose reduction (AIDR-6 3D) reconstruction in dynamic pulmonary CT perfusion. MATERIALS ANDMETHODS:
CTP examinations of 10 patients acquired at 100 kVp/50 mAs were reconstructed with filtered back projection (FBP) and AIDR-3D. Artificial noise was added to raw data (pre-reconstruction projection data) to simulate lower tube current scanning. Radiodensity (in Hounsfield units), noise, and perfusion values were compared.RESULTS:
There was no significant difference in noise between the full and simulated reduced tube current with AIDR-3D reconstruction (p = 1). There was significantly lower noise in lung tissue with AIDR-3D images when compared to reconstructions without AIDR-3D (p = 0.005) and no significant change in the radiodensity (p = 1; mean difference <6 HU). Mean perfusion values increased significantly at lower tube currents (25 and 12.5 mAs), compared to 50 mAs (p = 0.005). This effect was significantly greater in larger patients compared to thin patients.CONCLUSION:
AIDR-3D produced significantly lower noise images than FBP-based algorithms and maintained consistent noise levels in lung at 12.5 mAs, indicating this algorithm is suitable for reduced dose lung perfusion imaging. Iterative reconstruction allows significant radiation dose reduction of up to fourfold in smaller patients, and up to twofold in the medium/large size patients. The increase in perfusion values at 25% simulated tube currents is attributed to attenuation bias.
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Base de dados:
MEDLINE
Assunto principal:
Embolia Pulmonar
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Fibrose Pulmonar
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Doses de Radiação
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Algoritmos
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Tomografia Computadorizada por Raios X
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Enfisema
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article