Mitochondrially targeted redox probe reveals the variations in oxidative capacity of the haematopoietic cells.
Org Biomol Chem
; 13(24): 6686-9, 2015 Jun 28.
Article
em En
| MEDLINE
| ID: mdl-26006184
Both oxidative stress and mitochondrial dysfunction play roles in a myriad of pathological conditions. There is therefore a need for tools that possess the ability to measure the dynamics of oxidative capacity within the mitochondria, particularly those that can measure reversible changes. Here, we report a mitochondrially-targeted fluorescent redox sensor NpFR2, which can reversibly measure changes in the mitochondrial redox environment. The probe has been used to report on variations in oxidative capacity of the haematopoietic cells in bone marrow, thymus and spleen.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Hematopoéticas
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Espécies Reativas de Oxigênio
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Naftalimidas
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Corantes Fluorescentes
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Mitocôndrias
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article