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AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.
Herms, Albert; Bosch, Marta; Reddy, Babu J N; Schieber, Nicole L; Fajardo, Alba; Rupérez, Celia; Fernández-Vidal, Andrea; Ferguson, Charles; Rentero, Carles; Tebar, Francesc; Enrich, Carlos; Parton, Robert G; Gross, Steven P; Pol, Albert.
Afiliação
  • Herms A; Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain.
  • Bosch M; Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain.
  • Reddy BJ; Department of Developmental and Cell Biology, UC Irvine, Irvine, California 92697, USA.
  • Schieber NL; 1] The Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia [2] Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, Queensland 4072, Australia.
  • Fajardo A; Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain.
  • Rupérez C; Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain.
  • Fernández-Vidal A; 1] Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain [2] The Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia [3] Centre for Microscopy and Microanalysis, The Univers
  • Ferguson C; 1] The Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia [2] Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, Queensland 4072, Australia.
  • Rentero C; 1] Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain [2] Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona 08036, Spain.
  • Tebar F; 1] Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain [2] Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona 08036, Spain.
  • Enrich C; 1] Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain [2] Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona 08036, Spain.
  • Parton RG; 1] The Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia [2] Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, Queensland 4072, Australia.
  • Gross SP; Department of Developmental and Cell Biology, UC Irvine, Irvine, California 92697, USA.
  • Pol A; 1] Cell Compartments and Signaling Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain [2] Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona 08036, Spain [3] Institució Catalana de Re
Nat Commun ; 6: 7176, 2015 May 27.
Article em En | MEDLINE | ID: mdl-26013497
Lipid droplets (LDs) are intracellular organelles that provide fatty acids (FAs) to cellular processes including synthesis of membranes and production of metabolic energy. While known to move bidirectionally along microtubules (MTs), the role of LD motion and whether it facilitates interaction with other organelles are unclear. Here we show that during nutrient starvation, LDs and mitochondria relocate on detyrosinated MT from the cell centre to adopt a dispersed distribution. In the cell periphery, LD-mitochondria interactions increase and LDs efficiently supply FAs for mitochondrial beta-oxidation. This cellular adaptation requires the activation of the energy sensor AMPK, which in response to starvation simultaneously increases LD motion, reorganizes the network of detyrosinated MTs and activates mitochondria. In conclusion, we describe the existence of a specialized cellular network connecting the cellular energetic status and MT dynamics to coordinate the functioning of LDs and mitochondria during nutrient scarcity.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Quinases Ativadas por AMP / Ácidos Graxos / Gotículas Lipídicas / Microtúbulos / Mitocôndrias Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Quinases Ativadas por AMP / Ácidos Graxos / Gotículas Lipídicas / Microtúbulos / Mitocôndrias Idioma: En Ano de publicação: 2015 Tipo de documento: Article