Peptide 2-formylthiophenol esters do not proceed through a Ser/Thr ligation pathway, but participate in a peptide aminolysis to enable peptide condensation and cyclization.
Org Biomol Chem
; 13(25): 6922-6, 2015 Jul 07.
Article
em En
| MEDLINE
| ID: mdl-26013965
ABSTRACT
Peptide thiol salicylaldehyde (SAL) esters unexpectedly do not follow a Ser/Thr ligation pathway to react with peptides containing N-terminal Ser/Thr, but proceed towards a peptide aminolysis in DMSO. The reaction takes place even at a low substrate concentration (1 mM). The method has been successfully used to synthesize several natural cyclic peptides, with a high ratio of monocyclic to dimeric products.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Peptídeos Cíclicos
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Fenóis
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Compostos de Sulfidrila
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Aldeídos
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Aminas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article