Sirt1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet.

Liu, Xiaojun; Gao, Yong; Li, Meixia; Geng, Chao; Xu, Haifeng; Yang, Yaoguo; Guo, Yongjun; Jiao, Tao; Fang, Fude; Chang, Yongsheng

Liu, Xiaojun; Gao, Yong; Li, Meixia; Geng, Chao; Xu, Haifeng; Yang, Yaoguo; Guo, Yongjun; Jiao, Tao; Fang, Fude; Chang, Yongsheng.

Afiliação

Liu X; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College, Beijing 100005, China. Electronic address: xiaojunliu@ibms.pumc.edu.cn.
Gao Y; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
Li M; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Geng C; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
Xu H; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Interventional Therapy, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Yang Y; The Department of Vascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Guo Y; The Department of Clinical Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Jiao T; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
Fang F; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College, Beijing 100005, China. Electronic address: fangfd@vip.sina.com.
Chang Y; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College, Beijing 100005, China. Electronic address: changy@ibms.pumc.edu.cn.

J Hepatol ; 63(3): 713-21, 2015 Sep.

Article em En | MEDLINE | ID: mdl-26026874

Assuntos

Fígado Gorduroso/prevenção & controle; Heme Oxigenase-1/fisiologia; Fígado/efeitos dos fármacos; Protoporfirinas/farmacologia; Sirtuína 1/fisiologia; Animais; Células Cultivadas; Dieta Hiperlipídica; Resistência à Insulina; Fígado/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Mitocôndrias/efeitos dos fármacos; Proteína Tirosina Fosfatase não Receptora Tipo 1/fisiologia; Proteína de Ligação a Elemento Regulador de Esterol 1/fisiologia

Palavras-chave

HO-1; Inflammation; Metabolism; Mitochondrial biogenesis; SREBP-1c; Sirt1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Protoporfirinas / Heme Oxigenase-1 / Fígado Gorduroso / Sirtuína 1 / Fígado Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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