Zein-Based Nanoparticles Improve the Oral Bioavailability of Resveratrol and Its Anti-inflammatory Effects in a Mouse Model of Endotoxic Shock.

Penalva, Rebeca; Esparza, Irene; Larraneta, Eneko; González-Navarro, Carlos J; Gamazo, Carlos; Irache, Juan M

Penalva, Rebeca; Esparza, Irene; Larraneta, Eneko; González-Navarro, Carlos J; Gamazo, Carlos; Irache, Juan M.

Afiliação

Penalva R; Department of Pharmacy and Pharmaceutical Technology, Department of Microbiology, and #Centre for Nutrition Research, University of Navarra, 31080 Pamplona, Spain.
Esparza I; Department of Pharmacy and Pharmaceutical Technology, Department of Microbiology, and #Centre for Nutrition Research, University of Navarra, 31080 Pamplona, Spain.
Larraneta E; Department of Pharmacy and Pharmaceutical Technology, Department of Microbiology, and #Centre for Nutrition Research, University of Navarra, 31080 Pamplona, Spain.
González-Navarro CJ; Department of Pharmacy and Pharmaceutical Technology, Department of Microbiology, and #Centre for Nutrition Research, University of Navarra, 31080 Pamplona, Spain.
Gamazo C; Department of Pharmacy and Pharmaceutical Technology, Department of Microbiology, and #Centre for Nutrition Research, University of Navarra, 31080 Pamplona, Spain.
Irache JM; Department of Pharmacy and Pharmaceutical Technology, Department of Microbiology, and #Centre for Nutrition Research, University of Navarra, 31080 Pamplona, Spain.

J Agric Food Chem ; 63(23): 5603-11, 2015 Jun 17.

Article em En | MEDLINE | ID: mdl-26027429

Assuntos

Anti-Inflamatórios/administração & dosagem; Portadores de Fármacos/química; Choque Séptico/tratamento farmacológico; Estilbenos/administração & dosagem; Zeína/química; Administração Oral; Animais; Anti-Inflamatórios/química; Anti-Inflamatórios/farmacocinética; Disponibilidade Biológica; Modelos Animais de Doenças; Feminino; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Nanopartículas/química; Ratos; Ratos Wistar; Resveratrol; Estilbenos/química; Estilbenos/farmacocinética; Fator de Necrose Tumoral alfa/imunologia

Palavras-chave

anti-inflammatory; bioavailability; nanoparticles; resveratrol; zein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Choque Séptico / Estilbenos / Zeína / Portadores de Fármacos / Anti-Inflamatórios Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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